Hypocomplementaemic immune complex tubulointerstitial nephritis
نویسندگان
چکیده
We report a rare cause of rapidly progressive renal failure associated with low complement, positive ANA but negative anti DS-DNA. A renal biopsy demonstrated tubulointerstitial nephritis with positive immunoglobulin staining involving the interstitium and tubular basement membrane but glomerular sparing. A review of the literature and differential diagnosis are discussed.
منابع مشابه
IgG4-related disease should be considered in cases of hypocomplementemic immune-complex tubulointerstitial nephritis
Dear Sir, We read with great interest the paper of Gupta et al. concerning a case of hypocomplementaemic tubulointerstitial nephritis (TIN) [1]. Hypocomplementaemic immune complex TIN in the absence of autoimmune disorders is a rare condition, and only a limited number of cases have been reported, of which most have been labelled idiopathic [2]. However, in recent years, several case reports an...
متن کاملFatal acute hepatorenal failure during antimalarial-based combination treatment
pocomplementaemic idiopathic immune complex tubulointerstitial nephritis (TBIN) that we mentioned in our case report [1,2]. In the absence of this evidence, presence or absence of IgG4 disease in reference to our case remains a speculation. On reviewing the literature of IgG4 disease, we noted some important differences. Most of the cases of IgG4 disease have concurrent or subsequent systemic i...
متن کاملImmune Complex-Mediated Complement Activation in a Patient with IgG4-Related Tubulointerstitial Nephritis
A 59-year-old man was diagnosed with IgG4-related tubulointerstitial nephritis. His symptoms as well as laboratory and imaging findings were improved after initiation of steroid therapy. Serologically, he showed hypocomplementemia (C3 23 mg/dl, C4 <2 mg/dl, CH50 <7 U/ml) with high levels of IgG (IgG4 1,970 mg/dl) and immune complexes (C1q assay 8.1 μg/ml) and a low level of C1q (<2.0 mg/dl). Hi...
متن کاملIgG4-Related Tubulointerstitial Nephritis Associated with Membranous Nephropathy in Two Patients: Remission after Administering a Combination of Steroid and Mizoribine
We report two cases of Japanese men who presented with proteinuria, eosinophilia, hypocomplementemia, and high serum immunoglobulin G4 (IgG4) concentration and were diagnosed with membranous nephropathy associated with IgG4-related tubulointerstitial nephritis on renal biopsy. The typical renal lesions of IgG4-related disease are tubulointerstitial nephritis, which improves remarkably with ster...
متن کاملRituximab for the Treatment of IgG4-Related Tubulointerstitial Nephritis
Immunoglobulin type gamma 4 (IgG4)-related disease is a relatively newly described clinical entity characterized by a distinctive histopathological appearance, increased numbers of IgG4 positive plasma cells and often, but not always, elevated serum IgG4 concentrations. The most common renal manifestation of IgG4-related disease is tubulointerstitial nephritis marked with proteinuria, hematuria...
متن کامل